The three major filler brands in direct comparison
Juvéderm, Restylane, and Belotero dominate the European market for hyaluronic acid fillers. All three brands offer high-quality products – but with different technologies, rheologies, and main indications. It is crucial for doctors and clinics to know the differences to achieve the best results for each patient.
Juvéderm (Allergan/AbbVie): VYCROSS Technology
Juvéderm relies on the proprietary VYCROSS technology, which blends short- and long-chain hyaluronic acid molecules. The result: high cohesivity, smooth texture, and long-lasting effects (12–24 months depending on the product).
- Juvéderm Ultra Smile 2x0.55ml – Lips, perioral area. Soft, natural, with lidocaine.
- Juvéderm Ultra 2 2x0.55ml – Fine to medium wrinkles, superficial lines.
- Juvéderm Volite 2x1ml – Skin quality and hydration, biorevitalization.
- Juvéderm Volux 2x1ml – Structural filler for chin, jawline, strong lift.
Strengths: Long-lasting effect, smooth texture, broad product portfolio.
Special feature: All products contain lidocaine for maximum patient comfort.
Restylane (Galderma): NASHA & OBT Technology
Restylane uses two technologies: NASHA (Non-Animal Stabilized Hyaluronic Acid) for classic products and OBT (Optimal Balance Technology) for newer lines. NASHA products are known for their stability and precise placement.
- Restylane Volyme Lidocaine 1ml – Volume restoration in the mid-face, cheeks. High G-Prime, long-lasting.
- Restylane Refyne Lidocaine 1ml – Natural movement thanks to XpresHAn technology. Ideal for nasolabial folds in active patients.
Strengths: Precise placement, natural movement (XpresHAn), proven NASHA stability.
Special feature: XpresHAn products maintain their shape even with facial expressions – ideal for dynamic facial areas.
Belotero (Merz): CPM Technology
Belotero uses Cohesive Polydensified Matrix (CPM) technology, which allows for particularly homogeneous distribution in the tissue. The result: no Tyndall effect, ideal for superficial injections.
- Belotero Balance Lidocaine 1ml – Fine lines, periorbital area, superficial wrinkles. No Tyndall effect.
- Belotero Intense Lidocaine 1ml – Deep nasolabial folds, marionette lines, lip volume.
Strengths: Homogeneous tissue integration, no Tyndall effect, ideal for superficial areas.
Special feature: The only filler that can be safely used in the tear trough without Tyndall risk.
Direct comparison: Who wins where?
- Lips: Juvéderm Ultra Smile (volume & contour) or Belotero Balance (fine lines)
- Nasolabial folds: Restylane Refyne (movement) or Belotero Intense (deep filling)
- Cheeks/Volume: Juvéderm Volux or Restylane Volyme
- Tear trough: Belotero Balance (no Tyndall effect)
- Biorevitalization: Juvéderm Volite
Conclusion
All three brands are excellent – the choice depends on the indication, injection technique, and patient wishes. A well-stocked practice assortment combines products from all three lines.
Now in the Novamedo shop: Juvéderm, Restylane, and Belotero – all leading filler brands at a glance, delivered quickly.
