Profhilo Structura: Next-Gen Filler with NAHYCO for Physicians Explained

Profhilo Structura: BDDE-Free NAHYCO Technology for Structural Volume. Comparison with Profhilo H+L, Indications, and Combination Protocol for Physicians.

Profhilo Structura: The Evolution of Bio-Remodelling

Profhilo Structura 1x2ml from IBSA is the latest innovation in the Profhilo family – and a paradigm shift in aesthetic medicine. While the classic Profhilo H+L is designed for skin tightening and bio-remodelling without volume, Profhilo Structura combines NAHYCO technology with structural volume building for the first time.

What makes Profhilo Structura unique?

NAHYCO Hybrid Technology

Profhilo Structura is based on IBSA's patented NAHYCO technology (Native Hybrid Cooperative) – a thermal cross-linking of high-molecular and low-molecular hyaluronic acid without chemical cross-linking agents (no BDDE).

  • HA concentration: 32 mg/ml (highest concentration in the Profhilo family)
  • Cross-linking: Thermal (NAHYCO) – no BDDE, no chemical cross-linking agents
  • Consistency: Firm enough for structural support, soft enough for natural movement

Profhilo Structura vs. Profhilo H+L: The Comparison

Feature Profhilo Structura Profhilo H+L
HA Concentration 32 mg/ml 32 mg/ml (64mg/2ml)
Cross-linking NAHYCO (thermal) NAHYCO (thermal)
BDDE No No
Primary effect Volume + Structure Bio-Remodelling + Tightening
Injection depth Deep subcutaneous / supraperiosteal Subcutaneous (BAP technique)
Duration of effect Up to 6 months Up to 6 months
Sessions 2 (4 weeks apart) 2 (4 weeks apart)

Indications for Profhilo Structura

  • Cheek volume and midface lift
  • Sagging skin with volume loss (not just tightening needs)
  • Patients who desire natural volume without a classic filler look
  • Combination with Profhilo H+L for maximum bio-remodelling + volume
  • Neck and décolleté with volume loss

The Combination Protocol: Structura + H+L

The combination of both Profhilo products is the most advanced bio-remodelling protocol on the market:

  1. Session 1: Profhilo Structura (deep, structural) + Profhilo H+L (superficial, tightening)
  2. Session 2 (4 weeks later): Repeat
  3. Result: Maximum tightening + natural volume + bio-remodelling

Why NAHYCO without BDDE?

Classic fillers are chemically cross-linked with BDDE (Butanediol Diglycidyl Ether). IBSA has developed an alternative with NAHYCO that does not require this chemical cross-linker – with a potentially better biocompatibility profile and more natural integration into the tissue.

Conclusion for Practice

Profhilo Structura closes the gap between classic bio-remodelling (Profhilo H+L) and structural fillers. For patients who desire natural volume without a classic filler look, it is the ideal solution.

More about classic Profhilo: Profhilo vs. Skinbooster.

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Professional Solutions for Aesthetic and Regenerative Medicine

Our product range includes high-quality hyaluronic acid joint injections for regenerative medicine, premium dermal fillers for natural aesthetic results, and innovative Lemon Bottle products for targeted fat reduction. All products are intended exclusively for use by medical professionals.