Synvisc-One: Evidence-Based Single-Shot Viscosupplementation
Synvisc-One 48mg/6ml is based on Hylan G-F 20, a chemically modified hyaluronic acid with superior viscoelastic properties. As one of the most thoroughly studied single-shot preparations, it offers an evidence-based solution for patients with knee osteoarthritis.
What is Hylan G-F 20?
Unlike natural hyaluronic acid found in Durolane 60mg/3ml or Ostenil 20mg/2ml, Hylan G-F 20 is a chemically cross-linked hyaluronic acid. This cross-linking leads to increased viscosity and elasticity, longer residence time in the joint, improved shock absorption, and optimized lubrication.
Clinical Evidence: Over 20 Years of Research
- Significant pain reduction over 26 weeks (WOMAC scale)
- Improvement in joint function by up to 40%
- Reduced NSAID requirement by an average of 50%
- Delay of surgical interventions by an average of 2–3 years
- Over 10 million treatments worldwide, adverse event rate <5%
Comparison with other Single-Shot Preparations
| Feature | Synvisc-One | Durolane | Monovisc |
|---|---|---|---|
| Active Ingredient | Hylan G-F 20 (cross-linked) | Natural HA (NASHA) | Highly cross-linked HA |
| Concentration | 48 mg/6 ml | 60 mg/3 ml | 88 mg/4 ml |
| Volume | 6 ml | 3 ml | 4 ml |
| Duration of action | Up to 6 months | Up to 6 months | Up to 6 months |
Indications and Patient Selection
- Mild to moderate knee osteoarthritis (Kellgren-Lawrence Grade 2–3)
- Patients who have previously responded positively to Synvisc
- Working professionals with limited time
- Physically active patients
Treatment Protocol
A single intra-articular injection of 6 ml. If well tolerated, treatment can be repeated after 6 months. Bring Synvisc-One to room temperature (30 minutes), strictly aseptic conditions, joint aspiration recommended before injection in case of effusion.
Contraindications
- Known hypersensitivity to hylan products
- Acute joint infection or skin infection in the injection area
- Severe coagulation disorders
- Caution in case of bird/egg allergy (manufacturing process)
Alternative Preparations in Case of Intolerance
- Durolane 60mg/3ml – Natural HA, smaller volume
- Monovisc 88mg/4ml – Natural HA, highest concentration
- HyalOne 60mg/4ml – Natural HA, medium volume
Conclusion for Practice
Synvisc-One 48mg/6ml is a leading single-shot viscosupplementation with over 20 years of clinical evidence. The chemically cross-linked hyaluronic acid (Hylan G-F 20) offers superior viscoelastic properties and long-lasting pain relief with high safety.
Questions about Synvisc-One or other viscosupplementation preparations? Our expert team will be happy to advise you: info@novamedo.de
