Ellansé S vs. M: Which PCL Biostimulator is right for you?

Ellansé S vs. M: PCL Biostimulator with Immediate Volume and Collagen Stimulation. Comparison of Duration of Action (12 vs. 24 Months) and Indications for Physicians from Sinclair Pharma.

Ellansé: Immediate Volume + Long-Term Collagen Stimulation

Ellansé by Sinclair Pharma is the only biostimulator on the market that combines immediate volumetric effect with long-term collagen stimulation. The unique PCL (polycaprolactone) microsphere technology stimulates the body's own collagen production – for months to years. The difference between Ellansé S and M lies solely in the duration of effect.

Ellansé S 2x1ml – 12 Months

Ellansé S 2x1ml is the entry-level variant of the Ellansé family with an effective duration of approx. 12 months.

  • Active ingredient: PCL microspheres in CMC carrier gel
  • Immediate effect: Volume due to CMC gel (immediately visible)
  • Long-term effect: Collagen stimulation by PCL (12 months)
  • Indications: Nasolabial folds, cheek volume, facial contouring
  • Ideal for: First treatments, patients who prefer shorter commitment

Ellansé M 2x1ml – 24 Months

Ellansé M 2x1ml is the best-selling variant with an effective duration of approx. 24 months.

  • Active ingredient: PCL microspheres (larger particles than S) in CMC carrier gel
  • Immediate effect: Volume due to CMC gel (immediately visible)
  • Long-term effect: Collagen stimulation by PCL (24 months)
  • Indications: Cheek volume, facial contouring, deep wrinkles, hand rejuvenation
  • Ideal for: Experienced patients who prefer a longer duration of effect

S vs. M: The Direct Comparison

Feature Ellansé S Ellansé M
PCL Particle Size Smaller Larger
Immediate Volume Yes (CMC) Yes (CMC)
Collagen Stimulation 12 Months 24 Months
Total Duration of Effect ~12 Months ~24 Months
Ideal for First Treatment Experienced Patients
Reversibility Not reversible (no HA) Not reversible (no HA)

Important Note: Ellansé is not reversible

Unlike hyaluronic acid fillers, Ellansé cannot be dissolved with hyaluronidase. This requires:

  • Careful patient selection and education
  • Precise injection technique (no correction window)
  • Experience with biostimulators recommended

Ellansé vs. Other Biostimulators

Compared to Sculptra and Radiesse, Ellansé offers the unique advantage of immediate volumetric effect through the CMC carrier gel – the result is immediately visible, without waiting time.

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