Juvéderm Ultra 3 & Ultra 4: The Complete Guide for Practitioners

Juvéderm Ultra 3 & Ultra 4 Compared: Indications, Cross-Linking Degree, Duration of Effect, and Product Selection. Complete Guide to Allergan's Best-Selling Filler Series.

Juvéderm Ultra: The world's best-selling filler series

Juvéderm Ultra 3 and Ultra 4 from Allergan (AbbVie) are among the most frequently used dermal fillers worldwide. Both are based on the proven VYCROSS technology with 24 mg/ml hyaluronic acid and 0.3% lidocaine – the difference lies in the degree of cross-linking and thus in the indication.

Juvéderm Ultra 3 2x1ml

Juvéderm Ultra 3 2x1ml is the most versatile filler in the Ultra series – ideal for moderate wrinkles and lip volume.

  • Concentration: 24 mg/ml VYCROSS-HA
  • Lidocaine: 0.3%
  • Indications: Moderate nasolabial folds, marionette lines, lip volume & contour, perioral area
  • Injection depth: Mid to deep dermis
  • Duration of action: 9–12 months
  • Special feature: Optimal balance between softness and form stability – ideal for mobile areas

Juvéderm Ultra 4 2x1ml

Juvéderm Ultra 4 2x1ml is the stronger filler in the Ultra series – for deep wrinkles and pronounced volume deficits.

  • Concentration: 24 mg/ml VYCROSS-HA (higher degree of cross-linking than Ultra 3)
  • Lidocaine: 0.3%
  • Indications: Deep nasolabial folds, pronounced marionette lines, cheek volume, lower third of the face
  • Injection depth: Deep intradermal to subcutaneous
  • Duration of action: 12–15 months
  • Special feature: Higher G-Prime than Ultra 3 – more structural support

Ultra 3 vs. Ultra 4: The direct comparison

Feature Juvéderm Ultra 3 Juvéderm Ultra 4
Concentration 24 mg/ml 24 mg/ml
Degree of cross-linking Medium High
G-Prime Medium Medium-high
Consistency Softer Firmer
Main indication Lips & moderate wrinkles Deep wrinkles & volume
Injection depth Mid dermis Deep intradermal
Duration of action 9–12 months 12–15 months
Lidocaine 0.3% 0.3%

Indication-based selection

  • Lip volume & contour: Juvéderm Ultra 3 (softer, natural)
  • Nasolabial folds (moderate): Juvéderm Ultra 3
  • Nasolabial folds (deep): Juvéderm Ultra 4
  • Cheek volume: Juvéderm Ultra 4 or Juvéderm Voluma
  • Chin augmentation / Jawline: Juvéderm Volux

The complete Juvéderm family at Novamedo

Complete filler comparison: Juvéderm vs. Restylane vs. Belotero | Aftercare: Dermal filler aftercare

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