Polynucleotides (PDRN): The New Dimension in Skin Regeneration
Polynucleotides – also known as PDRN (Polydeoxyribonucleotide) – are the fastest-growing category in aesthetic injection medicine. Unlike hyaluronic acid fillers or collagen stimulators, polynucleotides act at a cellular level, stimulating the body's own tissue regeneration directly at the DNA level – for sustainable, biologically-based results.
What are Polynucleotides (PDRN)?
PDRN are highly purified DNA fragments, extracted from salmon sperm. They work via two main mechanisms:
- Salvage Pathway: PDRN fragments are taken up by cells and used as building blocks for DNA repair and cell proliferation.
- A2A Receptor Activation: PDRN activates adenosine A2A receptors, inhibits inflammation, and stimulates collagen & elastin production.
Croma PhilArt® – The Specialized PDRN Series
Croma Pharma (Austria) has developed one of the most advanced PDRN product lines with the PhilArt® series.
- PhilArt® 2ml – Basic formulation for general skin regeneration and bio-remodeling
- PhilArt® Eye 2ml – Specifically for the delicate eye area, dark circles & tear troughs
- PhilArt® Hair 2ml – Specifically for the scalp, stimulates hair follicles for alopecia
- PhilArt® Next 2ml – Most advanced formulation for intensive bio-remodeling
PDRN vs. Hyaluronic Acid vs. Collagen Stimulators
| Feature | PDRN (PhilArt®) | Hyaluronic Acid | Collagen Stimulator |
|---|---|---|---|
| Mechanism of Action | Cell Regeneration | Hydration & Volume | Collagen Formation |
| Immediate Effect | Low | Yes | Partial |
| Regeneration | Very Strong | Low | Strong |
| Anti-inflammatory | Yes | No | No |
| Combination | Ideal with HA & Fillers | Standalone | Standalone |
PhilArt® Treatment Protocol
- Frequency: 3–4 sessions at 2–4 week intervals
- Maintenance: 1–2 sessions per year
- Combination: Ideal as a base before or after filler treatments
- Technique: Intradermal microinjections or mesotherapy technique
