Hylane G-F 20: The Basis of Both Preparations
Synvisc Classic and Synvisc-One are based on the same active ingredient: Hylane G-F 20 – a chemically cross-linked hyaluronic acid from Sanofi with superior viscoelastic properties. The key difference lies in the treatment regimen: three injections vs. a single injection.
Synvisc Classic (3 x 2ml) – The Proven Three-Dose Series
Synvisc Classic (3 x 2ml) is the original – clinically proven for over 25 years and used millions of times worldwide.
- Active ingredient: Hylane G-F 20 (chemically cross-linked)
- Regimen: 3 injections of 2 ml each, at weekly intervals
- Total volume: 6 ml (3 x 2 ml)
- Duration of action: Up to 6 months
- Indication: Knee osteoarthritis
- Advantage: Step-by-step therapy, cumulative effect, longest clinical evidence
Synvisc-One (48mg/6ml) – The Single-Shot
Synvisc-One 48mg/6ml contains the same total amount of Hylane G-F 20 (48 mg in 6 ml) – but in a single injection.
- Active ingredient: Hylane G-F 20 (identical to Synvisc Classic)
- Regimen: 1 injection of 6 ml
- Total volume: 6 ml (1 x 6 ml)
- Duration of action: Up to 6 months
- Indication: Knee osteoarthritis
- Advantage: Maximum compliance, only one doctor's visit
Direct Comparison: Classic vs. One
| Feature | Synvisc Classic | Synvisc-One |
|---|---|---|
| Active ingredient | Hylane G-F 20 | Hylane G-F 20 |
| Total HA quantity | 48 mg | 48 mg |
| Total volume | 6 ml (3x2ml) | 6 ml (1x6ml) |
| Injections | 3 (weekly) | 1 |
| Duration of action | Up to 6 months | Up to 6 months |
| Compliance | 3 doctor's visits | 1 doctor's visit |
| Clinical evidence | 25+ years | 15+ years |
| Infection risk | 3 punctures | 1 puncture |
When Classic, When One?
- Synvisc Classic: Patients who prefer a gradual therapy – or for whom a single large injection (6 ml) is not possible (e.g., small joint volume, severe effusion)
- Synvisc-One: Patients with high compliance risk, working professionals, patients with long travel distances, needle-phobics
- Clinically equivalent: Both preparations deliver comparable results with the same total dose
Practical Tips for Practice
- For Synvisc-One: Joint aspiration before injection recommended for effusion (6 ml volume)
- Bring both preparations to room temperature (30 minutes)
- Strict aseptic conditions, ideally ultrasound-guided
- Repeatable after 6 months
Complete guide to Synvisc-One: Synvisc-One: Hylane G-F 20 for maximum joint relief. Comparison of all single-shot preparations: Durolane vs. Monovisc vs. Cingal.
